Summary:
CMTM6 Antibody Blocking Peptide
Cat：K114661P-Ag
| 【Derived From】： Synthetic |
| 【Amino Acid】： 133-183/183aa |
| 【Uniprot】： Q9NX76 |
| 【Gene ID】： 54918 |
| 【Application】： Blocking Peptide of K114661P Antibody |
| 【Purification】： HPLC |
| 【Bioactive】： Not tested |
Store:
| 【Storage】： Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| 【Formulation】： Lyophilized powder |
Background:
Master regulator of recycling and plasma membrane expression of PD-L1/CD274， an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes， where it protects PD-L1/CD274 from being targeted for lysosomal degradation， likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279， its receptor on T-cells， ultimately triggering T-cell anergy.
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