Summary:
TCF7 Antibody Blocking Peptide
Cat：K108542P-Ag
| 【Derived From】： Synthetic |
| 【Uniprot】： P36402 |
| 【Gene ID】： 6932 |
| 【Application】： Blocking Peptide of K108542P Antibody |
| 【Purification】： HPLC |
| 【Bioactive】： Not tested |
Store:
| 【Storage】： Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| 【Formulation】： Lyophilized powder |
Background:
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5’-WWCAAAG-3’) found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1， TLE2， TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
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