TNFRSF1B Antibody Blocking Peptide

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins， c-IAP1 and c-IAP2， which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown， however， c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2， which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.