H2AFY2 Antibody Blocking Peptide

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin， limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation， DNA repair， DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones， also called histone code， and nucleosome remodeling. May be involved in stable X chromosome inactivation.