ZNF598 Antibody Blocking Peptide

E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC)， a pathway that takes place when a ribosome has stalled during translation. Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10， RPS20/uS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide. Also acts as a component of the 4EHP-GYF2 complex， a multiprotein complex that acts as a repressor of translation initiation.