PRPF19 Antibody Blocking Peptide

Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770， PubMed:28076346， PubMed:29360106， PubMed:29301961， PubMed:30705154). Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly， its remodeling and is required for its activity. During assembly of the spliceosome， mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA， it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex， which contains PRPF19， is also involved in pre-mRNA splicing， transcription and transcription-coupled