SLC8B1 Antibody Blocking Peptide

Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion， by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762， PubMed:22829870， PubMed:23056385， PubMed:24898248， PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival， notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion， thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+?entry (SOCE) and Ca2+?release-activated Ca2+?(CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status， thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyt