FOXK1 Antibody Blocking Peptide

Transcriptional regulator involved in different processes such as glucose metabolism， aerobic glycolysis， muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5’-GTAAACA-3’) and can both act as a transcription activator or repressor， depending on the context (PubMed:17670796). Together with FOXK2， acts as a key regulator of metabolic reprogramming towards aerobic glycolysis， a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2)， phosphofructokinase， pyruvate kinase (PKLR) and lactate dehydrogenase)， while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting， when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in