Summary:
ARPC1B Antibody Blocking Peptide
Cat：K110216P-Ag
| 【Derived From】： Synthetic |
| 【Uniprot】： O15143 |
| 【Gene ID】： 10095 |
| 【Application】： Blocking Peptide of K110216P Antibody |
| 【Purification】： HPLC |
| 【Bioactive】： Not tested |
Store:
| 【Storage】： Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| 【Formulation】： Lyophilized powder |
Background:
Component of the Arp2/3 complex， a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539， PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm， providing the force for cell motility (PubMed:11741539， PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton， the Arp2/3 complex also promotes actin polymerization in the nucleus， thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization， leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Verified picture
