USP30 Antibody Blocking Peptide

Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins， such as RHOT1/MIRO1 and TOMM20， thereby blocking parkin’s ability to drive mitophagy (PubMed:18287522， PubMed:24896179， PubMed:25527291， PubMed:25621951). Preferentially cleaves ’Lys-6’- and ’Lys-11’-linked polyubiquitin chains， 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at ’Ser-65’ (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).