Summary:
MBTPS2 Antibody Blocking Peptide
Cat：K110644P-Ag
| 【Derived From】： Synthetic |
| 【Amino Acid】： 5-55/519aa |
| 【Uniprot】： O43462 |
| 【Gene ID】： 51360 |
| 【Application】： Blocking Peptide of K110644P Antibody |
| 【Purification】： HPLC |
| 【Bioactive】： Not tested |
Store:
| 【Storage】： Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| 【Formulation】： Lyophilized powder |
Background:
Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6， ATF6B， SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:11163209， PubMed:10805775). Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment， thereby releasing the N-terminal segment with a portion of the transmembrane segment attached (PubMed:10805775， PubMed:27380894， PubMed:9659902). Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription (PubMed:10805775， PubMed:27380894， PubMed:9659902). Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B) (PubMed:11163209). Involved in intramembrane proteolysis during bone formation (PubMed:27380894).
Verified picture
