SIAH2 Antibody Blocking Peptide

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:9334332， PubMed:11483518， PubMed:19224863). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:9334332， PubMed:11483518， PubMed:19224863). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:9334332， PubMed:11483518， PubMed:19224863). Triggers the ubiquitin-mediated degradation of many substrates， including proteins involved in transcription regulation (GPS2， POU2AF1， PML， NCOR1)， a cell surface receptor (DCC)， an antiapoptotic protein (BAG1)， and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:9334332， PubMed:11483518， PubMed:19224863). Mediates ubiquitination and proteasomal degradation of DYRK