Summary:
MRE11 Antibody Blocking Peptide
Cat：K110835P-Ag
| 【Derived From】： Synthetic |
| 【Amino Acid】： 650-700/708aa |
| 【Uniprot】： P49959 |
| 【Gene ID】： 4361 |
| 【Application】： Blocking Peptide of K110835P Antibody |
| 【Purification】： HPLC |
| 【Bioactive】： Not tested |
Store:
| 【Storage】： Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| 【Formulation】： Lyophilized powder |
Background:
Component of the MRN complex， which plays a central role in double-strand break (DSB) repair， DNA recombination， maintenance of telomere integrity and meiosis (PubMed:9651580， PubMed:9590181， PubMed:9705271， PubMed:11741547， PubMed:29670289). The complex possesses single-strand endonuclease activity and double-strand-specific 3’-5’ exonuclease activity， which are provided by MRE11 (PubMed:9651580， PubMed:9590181， PubMed:9705271， PubMed:11741547， PubMed:29670289). RAD50 may be required to bind DNA ends and hold them in close proximity (PubMed:9651580， PubMed:9590181， PubMed:9705271， PubMed:11741547， PubMed:29670289). This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates， and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580， PubMed:9590181， PubMed:9705271， PubMed:11741547， PubMed:29670289， PubMe
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