Summary:
TPX2 Antibody Blocking Peptide
Cat：K111082P-Ag
| 【Derived From】： Synthetic |
| 【Amino Acid】： 230-280/747aa |
| 【Uniprot】： Q9ULW0 |
| 【Gene ID】： 22974 |
| 【Application】： Blocking Peptide of K111082P Antibody |
| 【Purification】： HPLC |
| 【Bioactive】： Not tested |
Store:
| 【Storage】： Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| 【Formulation】： Lyophilized powder |
Background:
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at ’Thr-288’ and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis， GOLGA2 interacts with importin-alpha， liberating TPX2 from importin-alpha， allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.
Verified picture
