BRSK1 Antibody Blocking Peptide

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B， CDC25C， MAPT/TAU， RIMS1， TUBG1， TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1， acts as a key regulator of polarization of cortical neurons， probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in postmitotic neurons， leading to down-regulate WEE1 activity in polarized neurons. In neurons， localizes to synaptic vesicles and plays a role in neurotransmitter release， possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at ’Ser-131’， leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint r