KAT2A Antibody Blocking Peptide

Protein lysine acyltransferase that can act as a acetyltransferase， glutaryltransferase or succinyltransferase， depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on ’Lys-79’ (H3K79succ)， with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex， which provides succinyl-CoA， is required for histone succinylation (PubMed:29211711). In different complexes， functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes， acts as a histone acetyltransferase (PubMed:17301242， PubMed:19103755， PubMed:29211711). Has significant histone acetyltransferase activity with core histones， but not with nucleosome core particles (PubMed:17301242， PubMed:19103755). Acetylation of histones g