Summary:
TRADD Antibody Blocking Peptide
Cat：K111477P-Ag
| 【Derived From】： Synthetic |
| 【Amino Acid】： 30-80/312aa |
| 【Uniprot】： Q15628 |
| 【Gene ID】： 8717 |
| 【Application】： Blocking Peptide of K111477P Antibody |
| 【Purification】： HPLC |
| 【Bioactive】： Not tested |
Store:
| 【Storage】： Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| 【Formulation】： Lyophilized powder |
Background:
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12， leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses， apoptosis and activation of NF-kappa-B.
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