Summary:
RAPGEF3 Antibody Blocking Peptide
Cat：K111500P-Ag
| 【Derived From】： Synthetic |
| 【Amino Acid】： 785-835/923aa |
| 【Uniprot】： O95398 |
| 【Gene ID】： 10411 |
| 【Application】： Blocking Peptide of K111500P Antibody |
| 【Purification】： HPLC |
| 【Bioactive】： Not tested |
Store:
| 【Storage】： Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| 【Formulation】： Lyophilized powder |
Background:
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions， such as stress fibers and junctional actin.
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