ITCH Antibody Blocking Peptide

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14602072， PubMed:17028573， PubMed:16387660， PubMed:18718448， PubMed:18718449， PubMed:11046148， PubMed:19592251， PubMed:19116316， PubMed:19881509， PubMed:20491914， PubMed:20392206， PubMed:20068034， PubMed:23146885， PubMed:24790097， PubMed:25631046). Catalyzes ’Lys-29’-， ’Lys-48’- and ’Lys-63’-linked ubiquitin conjugation (PubMed:17028573， PubMed:18718448， PubMed:19131965， PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex， comprising also TNFAIP3， TAX1BP1 and RNF11， that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is form