Summary:
ARHGEF1 Antibody Blocking Peptide
Cat：K111520P-Ag
| 【Derived From】： Synthetic |
| 【Amino Acid】： 245-295/912aa |
| 【Uniprot】： Q92888 |
| 【Gene ID】： 9138 |
| 【Application】： Blocking Peptide of K111520P Antibody |
| 【Purification】： HPLC |
| 【Bioactive】： Not tested |
Store:
| 【Storage】： Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| 【Formulation】： Lyophilized powder |
Background:
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915， PubMed:9641916). Acts as GTPase-activating protein (GAP) for GNA12 and GNA13， and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:9641915， PubMed:9641916， PubMed:8810315， PubMed:30521495). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430).
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