Summary:
OCRL Antibody Blocking Peptide
Cat：K111526P-Ag
| 【Derived From】： Synthetic |
| 【Amino Acid】： 500-550/901aa |
| 【Uniprot】： Q01968 |
| 【Gene ID】： 4952 |
| 【Application】： Blocking Peptide of K111526P Antibody |
| 【Purification】： HPLC |
| 【Bioactive】： Not tested |
Store:
| 【Storage】： Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| 【Formulation】： Lyophilized powder |
Background:
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4，5-bisphosphate (PtdIns(4，5)P2) and phosphatidylinositol-3，4，5-bisphosphate (PtdIns(3，4，5)P3)， with the greatest catalytic activity towards PtdIns(4，5)P2 (PubMed:7761412， PubMed:15474001， PubMed:9430698， PubMed:10764818). Able also to hydrolyzes the 4-phosphate of inositol 1，4，5-trisphosphate and of inositol 1，3，4，5-tetrakisphosphate (PubMed:7761412， PubMed:25869668). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4，5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094， PubMed:22543976). Acts as a regulator of phagocytosis， hydrolyzing PtdIns(4，5)P2 to promote phagosome closure， through attenuation of PI3K signaling (PubMed:22072788).
Verified picture
