FMN2 Antibody Blocking Peptide

Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:22330775， PubMed:21730168).Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:22330775， PubMed:21730168).Involved in intracellular vesicle transport along actin fibers， providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity).Required for asymmetric spindle positioning， asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity).Plays a role in responses to DNA damage， cellular stress and hypoxia by protecting CDKN1A against degradation， and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502).Also acts in the nucleus: together with SPIRE1 and SPIRE2， promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480).Protects cel