BRCA1 Antibody Blocking Peptide

E3 ubiquitin-protein ligase that specifically mediates the formation of ’Lys-6’-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:12890688， PubMed:14976165， PubMed:16818604， PubMed:17525340， PubMed:12887909， PubMed:10500182， PubMed:19261748).It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688).The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair， ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688， PubMed:14976165， PubMed:20351172).Regulates centrosomal microtubule nucleation (PubMed:18056443).Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175， PubMed:12183412， PubMed:11836499， PubMed:19261748).Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909).Inhibits