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POLQ Antibody Blocking Peptide

Cat:K112920P-Ag

Summary:

【Derived From】: Synthetic
【Amino Acid】: 2430-2480/2590aa
【Uniprot】: O75417
【Gene ID】: 10721
【Application】: Blocking Peptide of K112920P Antibody
【Purification】: HPLC
【Bioactive】: Not tested

Store:

【Storage】: Store at -20℃,2 years.Avoid freeze/thaw cycles.
【Formulation】: Lyophilized powder

Background:

DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:25642963, PubMed:25643323).MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323).POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963).POLQ-mediated MMEJ may be required to promote the survival of cells with a compromised HR repair pathway, thereby preventing genomic havoc by resolving unrepaired lesions (By similarity).The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs. It then extends each strand from the base-paired region u

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