Summary:
POLE Antibody Blocking Peptide
Cat：K113101P-Ag
| 【Derived From】： Synthetic |
| 【Amino Acid】： 360-410/2286aa |
| 【Uniprot】： Q07864 |
| 【Gene ID】： 5426 |
| 【Application】： Blocking Peptide of K113101P Antibody |
| 【Purification】： HPLC |
| 【Bioactive】： Not tested |
Store:
| 【Storage】： Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| 【Formulation】： Lyophilized powder |
Background:
Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849).Participates in chromosomal DNA replication (By similarity).Required during synthesis of the leading DNA strands at the replication fork， binds at/or near replication origins and moves along DNA with the replication fork (By similarity).Has 3’-5’ proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity).Involved in DNA synthesis during DNA repair (PubMed:20227374， PubMed:27573199).Along with DNA polymerase POLD1 and DNA polymerase POLK， has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374).
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