EMC4 Antibody Blocking Peptide

Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835， PubMed:29809151， PubMed:29242231， PubMed:32459176， PubMed:32439656).Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835， PubMed:29809151， PubMed:29242231).Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835， PubMed:29809151).It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151， PubMed:29242231).By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology， with translocated N-terminus in the lumen of the ER， cont