Summary:
Recombinant human CDK4 protein
Cat：P02368
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-303aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CDK4 |
| 【Full Name】： cyclin-dependent kinase 4 |
| 【Uniprot】： P11802 |
| 【Gene ID】： 1019 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Pig) |
| 【Mol Mass】： 34kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family.This protein is highly similar to the gene products of S.cerevisiae cdc28 and S.pombe cdc2.It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression.The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a).This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb).Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers.
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