Summary:
Recombinant human MEK2(MAP2K2) protein
Cat：P02382
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-400aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： MEK2(MAP2K2) |
| 【Full Name】： Mitogen-activated protein kinase 2 |
| 【Uniprot】： P36507 |
| 【Gene ID】： 5605 |
| 【Species Reactivity】： Human Mouse Rat (Dog Chicken) |
| 【Mol Mass】： 44kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family.This kinase is known to play a critical role in mitogen growth factor signal transduction.It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3.The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome.The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.A pseudogene, which is located on chromosome 7, has been identified for this gene.
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