Summary:
Recombinant human BMI1 protein
Cat：P02385
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-324aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： BMI1 |
| 【Full Name】： BMI1 polycomb ring finger oncogene |
| 【Uniprot】： P35226 |
| 【Gene ID】： 648 |
| 【Species Reactivity】： Human (Bovine Mouse Cat Zebrafish Chicken Gorilla) |
| 【Mol Mass】： 40kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1).This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells.This protein also plays a central role in DNA damage repair.This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies.A pseudogene of this gene is found on chromosome X.Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
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