Summary:
Recombinant human CTSB protein
Cat：P02391
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-339aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CTSB |
| 【Full Name】： cathepsin B |
| 【Uniprot】： P07858 |
| 【Gene ID】： 1508 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Pig Sheep Chicken Monkey Gorilla) |
| 【Mol Mass】： 38kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes a member of the C1 family of peptidases.Alternative splicing of this gene results in multiple transcript variants.At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products.These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme.This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover.It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP).Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia.Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors.Multiple pseudogenes of this gene have been identified.
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