Summary:
Recombinant human DIABLO/SMAC protein
Cat：P02395
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-239aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： DIABLO/SMAC |
| 【Full Name】： Diablo homolog，mitochondrial |
| 【Uniprot】： Q9NR28 |
| 【Gene ID】： 56616 |
| 【Species Reactivity】： Human Mouse (Gorilla) |
| 【Mol Mass】： 27kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein.The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins.Overexpression of the encoded protein sensitizes tumor cells to apoptosis.A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64.Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, May 2013]
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