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Recombinant human casp1 protein

Cat：P02398

Summary:

【Derived From】： E.coli

【Endotoxin】： Not measured

【Amino Acid】： 1-404aa

【Purity】： ≥85% by SDS-PAGE.

【Name】： casp1

【Full Name】： caspase 1，apoptosis-related cysteine peptidase

【Uniprot】： P29466

【Gene ID】： 834

【Species Reactivity】： Human Mouse Rat (Zebrafish Horse Dog Pig Cat)

【Mol Mass】： 45kDa

【Application】： Immunology research

【Purification】： NI-NTA affinity purification

【Bioactive】： No activity experimental data, to be verified.

【Tag】： With a 6×His tag at the N/C-terminus.

【Concentration】： 1mg/ml by SDS-PAGE.

Store:

【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 10μg/ml. Dissolve the lyophilized protein in distilled water.)

【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 2-7 days， stored at < -20℃ for 1 year.

【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0.

Background:

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family.Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing.This gene has been shown to induce cell apoptosis and may function in various developmental stages.Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease.Alternative splicing results in transcript variants encoding distinct isoforms

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