Summary:
Recombinant human JNK2/MAPK9 protein
Cat：P02401
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 55-424aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： JNK2/MAPK9 |
| 【Full Name】： mitogen-activated protein kinase 9 |
| 【Uniprot】： P45984 |
| 【Gene ID】： 5601 |
| 【Species Reactivity】： Human Mouse Rat (Chicken) |
| 【Mol Mass】： 42kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The protein encoded by this gene is a member of the MAP kinase family.MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli.It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway.This gene and MAPK8 are also known as c-Jun N-terminal kinases.This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells.Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation.Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Verified picture
