Summary:
Recombinant human UCP2 protein
Cat：P02402
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-309aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： UCP2 |
| 【Full Name】： uncoupling protein 2 |
| 【Uniprot】： P55851 |
| 【Gene ID】： 7351 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Zebrafish Pig Gorilla) |
| 【Mol Mass】： 33kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP).UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak.UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane.They also reduce the mitochondrial membrane potential in mammalian cells.Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known.UCPs contain the three homologous protein domains of MACPs.This gene is expressed in many tissues, with the greatest expression in skeletal muscle.It is thought to play a role in nonshivering thermogenesis, obesity and diabetes.Chromosomal order is 5'-UCP3-UCP2-3'.
Verified picture
