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Recombinant human AGT protein

Cat:P02409

Summary:

【Derived From】: E.coli
【Endotoxin】: Not measured
【Amino Acid】: 44-485aa
【Purity】: ≥85% by SDS-PAGE.
【Name】: AGT
【Full Name】: angiotensinogen
【Uniprot】: P01019
【Gene ID】: 183
【Species Reactivity】: Human Mouse Rat (Cat Sheep Horse Gorilla)
【Mol Mass】: 48kDa
【Application】: Immunology research
【Purification】: NI-NTA affinity purification
【Bioactive】: N0
【Tag】: With a 6×His tag at the N/C-terminus.
【Concentration】: 1mg/ml by SDS-PAGE.

Store:

【Reconstitution】: Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
【Storage】: Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year.
【Formulation】: Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0.

Background:

he protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure.The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II.The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia.Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development.Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

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