Summary:
Recombinant human CDK5 protein
Cat：P02417
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-292aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CDK5 |
| 【Full Name】： cyclin-dependent kinase 5 |
| 【Uniprot】： Q00535 |
| 【Gene ID】： 1020 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Fruit fly) |
| 【Mol Mass】： 33kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins.Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation.Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis.In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7.Alternative splicing results in multiple transcript variants.
Verified picture
