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Recombinant human GSK3B protein

Cat:P02426

Summary:

【Derived From】: E.coli
【Endotoxin】: Not measured
【Amino Acid】: 31-357aa
【Purity】: ≥85% by SDS-PAGE.
【Name】: GSK3B
【Full Name】: glycogen synthase kinase 3 beta
【Uniprot】: P49841
【Gene ID】: 2932
【Species Reactivity】: Human Mouse Rat
【Mol Mass】: 37kDa
【Application】: Immunology research
【Purification】: NI-NTA affinity purification
【Bioactive】: N0
【Tag】: With a 6×His tag at the N/C-terminus.
【Concentration】: 1mg/ml by SDS-PAGE.

Store:

【Reconstitution】: Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
【Storage】: Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year.
【Formulation】: Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0.

Background:

The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily.It is involved in energy metabolism, neuronal cell development, and body pattern formation.Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease.Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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