Summary:
Recombinant human NAE1 protein
Cat：P02484
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 185-534aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： NAE1 |
| 【Full Name】： NEDD8 activating enzyme E1 subunit 1 |
| 【Uniprot】： Q13564 |
| 【Gene ID】： 8883 |
| 【Species Reactivity】： Human Mouse Rat (Chicken Monkey) |
| 【Mol Mass】： 40kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity.Later studies show that this gene product is localized in the nucleus and functions as a transcription factor.It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation.Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.
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