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CAS:7179-49-9
Appearance:White Powder
Storage: 2-8℃
Purity:potency＞850μg/mg
Description:
Lincomycin hydrochloride is a narrow-spectrum antibiotic, similar to erythromycin, has antibacterial effect on most gram-positive bacteria, but all Gram-negative bacteria (including erythromycin sensitive meningococcus, gonococcus, Haemophilus influenzae, etc.) are resistant to it. Lincomycin hydrochloride acts on the 50S subunit of the ribosomes of sensitive bacteria, preventing the extension of the peptide chain and thus inhibiting protein synthesis in bacterial cells. Cross-linking is formed in the peptidyl transferase ring region of 23S rRNA, which inhibits bacterial protein synthesis.
Use and synthesis method:
Biochemical reagent, biochemical experimental research, can be used in molecular biology and tissue culture (prevention of microbial contamination and resistance screening). It has good antibacterial effect on anaerobic bacteria, including tetanus bacillus, corynebacterium diphtheriae and Bacillus perfringens. It is not active against Enterococcus, meningococcus, Neisseria gonorrhoeae, Haemophilus influenzae and other gram-negative bacteria and fungi. There is no cross-resistance between the product and penicillin, chloramphenicol, cephalosporins and tetracycline, and partial cross-resistance with macrolide. It is generally a bacteriostatic agent, but at high concentration, it also has a bactericidal effect on some bacteria.
Solubility:
Soluble in water, slightly soluble in ethanol (96%), very slightly soluble in acetone.
Note :
(1) For cell experiments, after dissolution, must be filtered with disposable needle filterto remove bacteria.
(2) For your safety and health, please wear a lab coat and wear disposable gloves.
Note：Product information may be optimized and upgraded. Please refer to the actual label information for accuracy.
