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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > SAR-20347CAS：1450881-55-6
Molecular Formula：C21H18ClFN4O4
Molecular Weight：444.84
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1450881-55-6 |
| Name | SAR-20347 |
| Molecular Formula | C21H18ClFN4O4 |
| Molecular Weight | 444.84 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28502117 |
| SMILES | C1COCCN1C(=O)C2=CC=C(C=C2)NC3=C(N=C(O3)C4=C(C=CC=C4Cl)F)C(=O)N |
| InChIKey | C1COCCN1C(=O)C2=CC=C(C=C2)NC3=C(N=C(O3)C4=C(C=CC=C4Cl)F)C(=O)N |
| InChI | InChI=1S/C21H18ClFN4O4/c22-14-2-1-3-15(23)16(14)19-26-17(18(24)28)20(31-19)25-13-6- 4-12(5-7-13)21(29)27-8-10-30-11-9-27/h1-7，25H，8-11H2，(H2，24，28) |
| PubChem CID | 71727668 |
| Target Point | JAK；Tyk2 |
| Passage | JAK/STAT Signaling |
| Background | SAR-20347 is an inhibitor of TYK2, JAK1, JAK2 and JAK3. |
| Biological Activity | SAR-20347 is an inhibitor of TYK2， JAK1， JAK2 and JAK3 with IC50s of 0.6， 23， 26 and 41 nM， respectively.[1] |
| Data Literature Source | [1]. Works MG， et al. Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis. J Immunol. 2014 Oct 1;193(7):3278-87. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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