{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > EZ-482CAS：1016456-76-0
Molecular Formula：C23H19ClN4O5S
Molecular Weight：498.94
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 1016456-76-0 |
| Name | EZ-482 |
| Molecular Formula | C23H19ClN4O5S |
| Molecular Weight | 498.94 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CN1C(=O)C2=CC=CC=C2C(=N1)CC(=O)NC3=C(C=CC(=C3)S(=O)(=O)NC4=CC(=CC=C4)Cl)O |
| InChIKey | CLWDCBBEVQRZLY-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H19ClN4O5S/c1-28-23(31)18-8-3-2-7-17(18)19(26-28)13-22(30)25-20-12-16(9-10-21(20)29)34(32，33)27-15-6-4-5-14(24)11-15/h2-12，27，29H，13H2，1H3，(H，25，30) |
| PubChem CID | 24673104 |
| Target Point | ApoE |
| Passage | Others |
| Background | EZ-482 is a novel ligand of apolipoprotein (apoE) that binds to sites in the C-terminal domain of apoE. |
| Biological Activity | EZ-482， a novel ligand of apolipoprotein (apoE)， binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas[1]. |
| IC50 | Kd: 5-10μM(apoE3 and apoE4)[1] |
| Data Literature Source | [1]. Tridib Mondal，et al. ApoE: In Vitro Studies of a Small Molecule Effector. Biochemistry. 2016 May 10;55(18):2613-21. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
