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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Dyclonine HydrochlorideCAS：536-43-6
Molecular Formula：C18H28ClNO2
Molecular Weight：325.87
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 536-43-6 |
| Name | Dyclonine Hydrochloride |
| Molecular Formula | C18H28ClNO2 |
| Molecular Weight | 325.87 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-633-6 |
| MDL | MFCD00035386 |
| SMILES | CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2.Cl |
| InChIKey | KNZADIMHVBBPOA-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H，2-6，11-15H2，1H3;1H |
| PubChem CID | 68304 |
| Target Point | ALDH |
| Passage | Metabolic Enzyme&Protease |
| Background | Dyclonine Hydrochloride is an effective ALDH covalent inhibitor with sensitization activity to target cancer cells. It is also a local anesthetic that blocks the transmission of various nerve impulses or stimuli, suppressing touch and pain. |
| Biological Activity | Dyclonine Hydrochloride是一种口服有效的ALDH共价抑制剂，对ALDH2的IC50为35μM，对ALDH3A1的IC50为76μM。对靶向癌细胞具有增敏作用和抗菌作用。也是一种局部麻醉剂，阻断各种神经冲动或刺激的传递，抑制触觉和疼痛。[1-3] |
| IC50 | ALDH2: 35μM(IC50);ALDH3: 76μM(IC50)[1] |
| Data Literature Source | [1]. Khanna M，et al. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. J Biol Chem. 2011 Dec 16;286(50): 43486-94. [2]. Okazaki S，et al. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget. 2018 Sep 18;9(73): 33832-33843. [3]. Khanna M，et al. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. J Biol Chem. 2011 Dec 16;286(50): 43486-94. |
| Unit | Bottle |
| Specification | 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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