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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > N-EthylmaleimideCAS：128-53-0
Molecular Formula：C6H7NO2
Molecular Weight：125.13
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 128-53-0 |
| Name | N-Ethylmaleimide |
| Molecular Formula | C6H7NO2 |
| Molecular Weight | 125.13 |
| Solubility | Soluble in Water/DMSO ≥2mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 204-892-4 |
| MDL | MFCD00005509 |
| SMILES | CCN1C(=O)C=CC1=O |
| InChIKey | HDFGOPSGAURCEO-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H，2H2，1H3 |
| PubChem CID | 4362 |
| Target Point | Cysteine Protease |
| Passage | Metabolic Enzyme&Protease |
| Background | It is an irreversible cysteine protease inhibitor that specifically inhibits phosphate transport in mitochondria. It can inhibit prolyl endopeptidase. |
| Biological Activity | N-Ethylmaleimide 来源于马来酸，能使游离的巯基烷基化。是一种不可逆的半胱氨酸蛋白酶抑制剂，能特异性地抑制线粒体中的磷酸盐转运，可抑制脯氨酰内肽酶，其 IC50 值为 6.3 μM，可用于修饰蛋白质和肽中的半胱氨酸残基。[1-3] |
| IC50 | prolyl endopeptidase: 6.376μM(IC50)[1] |
| Data Literature Source | [1]. Yellaturu CR，et al. N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A. J Biol Chem. 2002 Oct 18;277(42): 40148-55. [2]. Matsuda H，et al. Roles of capsaicin-sensitive sensory nerves，endogenous nitric oxide，sulfhydryls，and prostaglandins in gastroprotection by momordin Ic，an oleanolic acid oligoglycoside，on ethanol-induced gastric mucosal lesions in rats. Life Sci. 1999;65(2): PL27-32. [3]. Moriyama A，et al. Porcine muscle prolyl endopeptidase and its endogenous substrates. J Biochem. 1988 Jul;104(1): 112-7. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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