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My CartCAS：1370468-36-2
Molecular Formula：C49H55N9O7
Molecular Weight：882.02
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1370468-36-2 |
| Name | Elbasvir |
| Molecular Formula | C49H55N9O7 |
| Molecular Weight | 882.02 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD30829850 |
| SMILES | CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC4=C(C=C3)N5[C@@H](OC6=C(C5=C4)C=CC(=C6)C7=CN=C(N7)[C@@H]8CCCN8C(=O)[C@H](C(C)C)NC(=O)OC)C9=CC=CC=C9)NC(=O)OC |
| InChIKey | BVAZQCUMNICBAQ-PZHYSIFUSA-N |
| InChI | InChI=1S/C49H55N9O7/c1-27(2)41(54-48(61)63-5)45(59)56-20-10-14-37(56)43-50-25-34(52-43)30-17-19-36-32(22-30)23-39-33-18-16-31(24-40(33)65-47(58(36)39)29-12-8-7-9-13-29)35-26-51-44(53-35)38-15-11-21-57(38)46(60)42(28(3)4)55-49(62)64-6/h7-9，12-13，16-19，22-28，37-38，41-42，47H，10-11，14-15，20-21H2，1-6H3，(H，50，52)(H，51，53)(H，54，61)(H，55，62)/t37-，38-，41-，42-，47-/m0/s1 |
| PubChem CID | 71661251 |
| Target Point | HCV |
| Passage | Anti-infection |
| Background | It is a hepatitis C virus non-structural protein 5A (HCV NS5A) inhibitor. |
| Biological Activity | Elbasvir 是一种丙型肝炎病毒非结构蛋白 5A（HCV NS5A）抑制剂，对基因型 1a、1b 和 2a 的 EC50 分别为 4、3 和 3 nM。[1] |
| Data Literature Source | [1]. Liu R，et al. Susceptibilities of genotype 1a，1b，and 3 hepatitis C virus variants to the NS5A inhibitor elbasvir. Antimicrob Agents Chemother. 2015 Nov;59(11): 6922-9. [2]. Lahser FC，et al. The Combination of Grazoprevir，a Hepatitis C Virus (HCV) NS3/4A Protease Inhibitor，and Elbasvir，an HCV NS5A Inhibitor，Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons. Antimicrob Agents Chemother. 2016 Apr 22;60(5): 2954-64. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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