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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Eltrombopag OlamineCAS：496775-62-3
Molecular Formula：C29H36N6O6
Molecular Weight：564.63
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 496775-62-3 |
| Name | Eltrombopag Olamine |
| Molecular Formula | C29H36N6O6 |
| Molecular Weight | 564.63 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22380664 |
| Target Point | Thrombopoietin Receptor |
| Passage | Immunology&Inflammation |
| Background | It is a thrombopoietin-receptor non-peptide agonist. |
| Biological Activity | Eltrombopag Olamine（Eltrombopag 二乙醇胺盐）是一种口服活性血小板生成素受体非肽激动剂。 具有造血活性，可用于心血管研究。对耐多药的金黄色葡萄球菌也有很强的抑制作用。还能诱导肝细胞癌（HCC）的细胞凋亡[1-5]。 |
| IC50 | thrombopoietin receptor: 0.69μM(IC50)[1] |
| Data Literature Source | [1]. Erickson-Miller CL，et al. Preclinical activity of eltrombopag (SB-497115)，an oral，nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009 Feb;27(2): 424-30. [2]. Erickson-Miller CL，et al. Discovery and characterization of a selective，nonpeptidyl thrombopoietin receptor agonist. Exp Hematol. 2005 Jan;33(1): 85-93. [3]. Lee H，et al. Repurposing Eltrombopag for Multidrug Resistant Staphylococcus aureus Infections. Antibiotics (Basel). 2021 Nov 9;10(11): 1372. [4]. Zhu J，et al. Identification of Eltrombopag as a Repurposing Drug Against Staphylococcus epidermidis and its Biofilms. Curr Microbiol. 2021 Apr;78(4): 1159-1167. [5]. Kurokawa T，et al. The Eltrombopag antitumor effect on hepatocellular carcinoma. Int J Oncol. 2015 Nov;47(5): 1696-702. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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