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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > EltrombopagCAS：496775-61-2
Molecular Formula：C25H22N4O4
Molecular Weight：442.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 496775-61-2 |
| Name | Eltrombopag |
| Molecular Formula | C25H22N4O4 |
| Molecular Weight | 442.47 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD20926253 |
| SMILES | C1=CC=C(C=C1)CCSC2=C(C=CC=N2)C(=O)O |
| InChIKey | UZERZZRWECLIKE-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H13NO2S/c16-14(17)12-7-4-9-15-13(12)18-10-8-11-5-2-1-3-6-11/h1-7，9H，8，10H2，(H，16，17) |
| PubChem CID | 888706 |
| Target Point | Thrombopoietin Receptor |
| Passage | Immunology&Inflammation |
| Background | It is a thrombopoietin-receptor non-peptide agonist. |
| Biological Activity | Eltrombopag 属于biarylhydrazone小分子，是一种thrombopoietin receptor (TpoR)的非肽类激动剂，用于治疗慢性丙型肝炎相关的血小板减少和慢性免疫性(自发的)血小板减少(ITP)。[1-2] |
| Data Literature Source | [1]. Erickson-Miller CL，et al. Preclinical activity of eltrombopag (SB-497115)，an oral，nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009 Feb;27(2): 424-30. [2]. Erickson-Miller CL，et al. Discovery and characterization of a selective，nonpeptidyl thrombopoietin receptor agonist. Exp Hematol. 2005 Jan;33(1): 85-93. [3]. Lee H，et al. Repurposing Eltrombopag for Multidrug Resistant Staphylococcus aureus Infections. Antibiotics (Basel). 2021 Nov 9;10(11): 1372. [4]. Zhu J，et al. Identification of Eltrombopag as a Repurposing Drug Against Staphylococcus epidermidis and its Biofilms. Curr Microbiol. 2021 Apr;78(4): 1159-1167. [5]. Kurokawa T，et al. The Eltrombopag antitumor effect on hepatocellular carcinoma. Int J Oncol. 2015 Nov;47(5): 1696-702. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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