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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > EntrectinibCAS：1108743-60-7
Molecular Formula：C31H34F2N6O2
Molecular Weight：560.64
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to light yellow Solid
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| CAS | 1108743-60-7 |
| Name | Entrectinib |
| Molecular Formula | C31H34F2N6O2 |
| Molecular Weight | 560.64 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Off-white to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28129099 |
| SMILES | CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6 |
| InChIKey | HAYYBYPASCDWEQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5，15-19，24，34H，6-14H2，1H3，(H2，35，36，37，40) |
| PubChem CID | 25141092 |
| Target Point | ROS Kinase;Trk Receptor;Anaplastic lymphoma kinase (ALK) |
| Passage | Protein Tyrosine Kinase/RTK;Neuronal Signaling;Angiogenesis |
| Background | It is a potent, orally active and central neuroactive inhibitor of Trk, ROS1 and ALK. |
| Biological Activity | Entrectinib是一种具有口服活性、BBB穿透性和中心活性的TrkA/B/C、ROS1和ALK抑制剂，其IC50值分别为1、3、5、12和7 nM。能诱导癌细胞凋亡和周期停滞，具有抗肿瘤活性，并能减轻博莱霉素诱导的小鼠肺纤维化。[1-3] |
| IC50 | TrkA: 1nM(IC50);TrkB: 3nM(IC50);ROS1: 12nM(IC50);ALK: 7nM(IC50)[1] |
| Data Literature Source | [1]. Ardini E，et al. Entrectinib，a Pan-TRK，ROS1，and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. Mol Cancer Ther. 2016 Apr;15(4): 628-39. [2]. Miao Y，et al. Entrectinib ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β1 signaling pathway. Int Immunopharmacol. 2022 Dec;113(Pt B): 109427. [3]. Iyer R，et al. Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model. Cancer Lett. 2016 Mar 28;372(2): 179-86. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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