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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > EpoxomicinCAS：134381-21-8
Molecular Formula：C28H50N4O7
Molecular Weight：554.72
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 134381-21-8 |
| Name | Epoxomicin |
| Molecular Formula | C28H50N4O7 |
| Molecular Weight | 554.72 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD03791061 |
| SMILES | CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)[C@]1(CO1)C)NC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)C |
| InChIKey | DOGIDQKFVLKMLQ-JTHVHQAWSA-N |
| InChI | InChI=1S/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-22(18(7)33)26(37)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18，20-23，33H，11-14H2，1-10H3，(H，29，37)(H，30，38)(H，31，36)/t16-，17-，18+，20-，21-，22-，23-，28+/m0/s1 |
| PubChem CID | 11226684 |
| Target Point | Proteasome |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a potent, selective and irreversible proteasome inhibitor. |
| Biological Activity | Epoxomicin 是一种含环氧酮的天然产物，也是一种强效、选择性和不可逆的蛋白酶体抑制剂。能与蛋白酶体的 LMP7、X、MECL1 和 Z 催化亚基共价结合，主要抑制糜蛋白酶样活性，可穿过血脑屏障，具有很强的抗肿瘤和抗炎活性。[1-5] |
| Data Literature Source | [1]. Hanada M，et al. Epoxomicin，a new antitumor agent of microbial origin. J Antibiot (Tokyo). 1992 Nov;45(11): 1746-52. [2]. Kim KB，et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett. 1999 Dec 6;9(23): 3335-40. [3]. Meng L，et al. Epoxomicin，a potent and selective proteasome inhibitor，exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18): 10403-8. [4]. Garrett IR，et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest. 2003 Jun;111(11): 1771-82. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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