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My Cart> Small Molecule Compounds > Anti-Infection > Antiviral > Daclatasvir DihydrochlorideCAS：1009119-65-6
Molecular Formula：C40H52Cl2N8O6
Molecular Weight：811.8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1009119-65-6 |
| Name | Daclatasvir Dihydrochloride |
| Molecular Formula | C40H52Cl2N8O6 |
| Molecular Weight | 811.8 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD25541736 |
| SMILES | CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC.Cl.Cl |
| InChIKey | BVZLLUDATICXCI-JMSCDMLISA-N |
| InChI | InChI=1S/C40H50N8O6.2ClH/c1-23(2)33(45-39(51)53-5)37(49)47-19-7-9-31(47)35-41-21-29(43-35)27-15-11-25(12-16-27)26-13-17-28(18-14-26)30-22-42-36(44-30)32-10-8-20-48(32)38(50)34(24(3)4)46-40(52)54-6;;/h11-18，21-24，31-34H，7-10，19-20H2，1-6H3，(H，41，43)(H，42，44)(H，45，51)(H，46，52);2*1H/t31-，32-，33-，34-;;/m0../s1 |
| PubChem CID | 25154713 |
| Target Point | HCV |
| Passage | Anti-infection |
| Background | It is a highly selective inhibitor of HCV NS5A. |
| Biological Activity | Daclatasvir dihydrochloride 是一种强效口服活性 HCV NS5A 蛋白抑制剂，对多种 HCV 复制基因型的 EC50s 为 9-146 pM。达卡他韦二盐酸盐也是一种有机阴离子转运多肽 1B（OATP1B）和 OATP1B3 抑制剂，IC50 分别为 1.5 μM 和 3.27 μM。[1-3] |
| IC50 | OATP1B: 1.5μM(IC50);OATP1B3: 3.27μM(IC50)[1] |
| Data Literature Source | [1]. Furihata T，et al. Different interaction profiles of direct-acting anti-hepatitis C virus agents with human organic anion transporting polypeptides. Antimicrob Agents Chemother. 2014 Aug;58(8): 4555-64. [2]. Gao M，et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature. 2010 May 6;465(7294): 96-100. [3]. Lee C，et al. The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein. Virology. 2011 May 25;414(1): 10-8. [4]. Wang C，et al，O'Boyle DR 2nd，Gao M，Fridell RA. In vitro activity of BMS-790052 on hepatitis C virus genotype 4 NS5A. Antimicrob Agents Chemother. 2012 Mar;56(3): 1588-90. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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