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My CartCAS：90038-01-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 90038-01-0 |
| Name | Detomidine Hydrochloride |
| Molecular Formula | C12H15ClN2 |
| Molecular Weight | 222.71 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD17292784 |
| SMILES | CC1=C(C(=CC=C1)CC2=CN=CN2)C.Cl |
| InChIKey | OIWRDXKNDCJZSM-UHFFFAOYSA-N |
| InChI | InChI=1S/C12H14N2.ClH/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12;/h3-5，7-8H，6H2，1-2H3，(H，13，14);1H |
| PubChem CID | 56031 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling |
| Background | It is an effective α2-adrenergic agonist; Can be used to promote stability, relieve pain related research. |
| Biological Activity | Detomidine Hydrochloride 是咪唑衍生物，是一种有效的α2-肾上腺素能激动剂。具有剂量依赖性镇痛作用。[1-2] |
| In Vivo | α-2 肾上腺素受体拮抗剂(yohimbine，rauwolscine and idazoxan)都能抑制地托咪定的镇静作用。[1]静脉注射地托咪定(10微克/千克，马)心率(HR)、心脏指数(CI)、氧转运(O2TR)显著降低，2分钟时SAPm、全身血管阻力(SVR)和氧利用系数(O2CU)显著升高。[2] |
| Data Literature Source | [1]. Virtanen R，et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine，a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1): 30-7. [2]. Still J，et al. Cardiovascular and respiratory effects of detomidine in isoflurane-anaesthetised horses. J S Afr Vet Assoc. 1996 Dec;67(4): 199-203. |
| Unit | Bottle |
| Specification | 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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